Volume : IV, Issue : X, October - 2015

Anticardiolipin antibodies in patients of Explained Vs Unexplained Abortions

Goel Neha, Tuli Anita

Abstract :

Background : Abortion is termination of pregnancy by any means before the fetus is sufficiently developed to survive on its own. The growing recognition that in this group of patients there may be an immunologic basis aroused interest in research workers. The anticardiolipin antibodies (aCL) which are commonly associated with recurrent pregnancy loss are lgG and lgM. lgM antibody is the largest immunoglobulin and first to appear in an immune response. Women with phospholipid antibodies have a fetal loss of 90% when no specific treatment is given during pregnancy so this study was planned to find anticardiolipin antibody levels (IgM & IgG) in patients of Abortions. Material/Methods: A total of 125 pregnant subjects were included in the study which includes study group (75 subjects) and a control group (50 subjects). Their blood was tested to assess the levels of IgM & IgG aCL by enzyme–linked immunosorbent assay (ELISA). Result : IgG anticardiolipin antibodies were raised in 16.66% of explained vs. 30.7% of unexplained abortion. IgM anticardiolipin antibodies were raised in 83.3% of the explained vs. 4.35% of unexplained abortions. Conclusion : Patients with increased IgM & IgG levels indicate a higher antibody burden with greater antigenic affinities explaining IgM & IgG mediated pregnancy wastage.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Goel Neha, Tuli Anita Anticardiolipin antibodies in patients of Explained Vs Unexplained Abortions International Journal of Scientific Research, Vol : 4, Issue : 10 October 2015

Number of Downloads : 1064

References :