Volume : VIII, Issue : V, May - 2019

Anticholinergic toxin induced Delirium and rare clinical sign of Carphologia, observed in critical care

Dr Deepa Banjan, Dr Amitanshu Hazare, Dr Rohan Modase, Dr Suprima Parkhi, Dr Maruti Wakode, Dr Neel Sharma

Abstract :

Delirium is a common presentation in Intensive care units treating neurological emergencies. Anticholinergic toxicity [ anti –Ach] is one of the causes of Delirium. Atropine, Hyoscine, scopolamine, belladonna, Deadly night shade [ Mandrake], [Stinking Night Shade] Hyocimus Niger and Jimson weed or Datura seeds are anticholinergic toxins. Acute onset Delirium without any prior history of psychiatric illness, is the most common symptom of anticholinergic toxin ingestion or exposure.1 Accidental consumption via traditional medical practioners or quacks often use crude extracts of anticholinergic drugs that lead to delirium, hallucinations, stupor, irrelevant talk and raised body temperature. Atropine, an anticholinergic drug, is also given as an antidote to Organophosphate toxicity in humans. Delirium is also seen in Atropinized patients. Central Anticholinergic syndrome CAS, has been described in Anaesthesia.19. Carphologia means "to behave as though one were collecting straw" First mentioned in the writings of Aristaeus. Carphologia, Crocydismus or Floccillation is described as “picking at clothes or bed linen”. It is an important clinical sign seen in agitated Delirium due to anticholinergic poisoning. In this retrospective cohort study of various forms of delirium cases, the Authors studied only anticholinergic toxicity related Delirium in 21 patients. Pre–and post–treatment recovery scores of organic deliriums were compared using DSR–98–16 item scale as a tool at onset and recovery. All patients showed dramatic complete recovery within 24 hrs of withdrawal of the drug. The study was conducted in patients to observe features of Delirium in Anticholinergic toxicity, the differences between delirium seen in Synthetic Vs natural anticholinergic extracts and to Calculate the optimum dose of Anticholinergic atropine as therapeutic agent as per bodyweight for minimising delirium & toxicity in OPC patients under critical care.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

ANTICHOLINERGIC TOXIN INDUCED DELIRIUM AND RARE CLINICAL SIGN OF CARPHOLOGIA, OBSERVED IN CRITICAL CARE, Dr Deepa Banjan, Dr Amitanshu Hazare, Dr Rohan Modase, Dr Suprima Parkhi, Dr Maruti Wakode, Dr Neel Sharma INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-5 | May-2019

Number of Downloads : 993

References :