Volume : IX, Issue : II, February - 2020

Antinociceptive Activity of Ethanolic Neem (Azadirachta Indica) Leaf Extract (ENLE) Through Opioid Pathway in Adult Rats

Dr. Anupam Sharma, Dr. Vipin Kumar

Abstract :

Aims: To evaluate antinociceptive activity of ethanolic neem leaf extract (ENLE) and determine involvement of opioidergic pathway in its effect. Methods and Material: The antinociceptive activity of ENLE was studied using hot plate method. Two different doses of ENLE (50mg/kg and 100 mg/kg, p.o.) were administered in adult rats. Morphine (1 mg/kg, s.c.) was used as reference drug. To determine opioidergic pathway, pre–treated rats with naloxone (1mg/kg, i.p.) were used. Statistical analysis used: Statistical analysis was done by one way ANOVA followed by Least significant difference test. Results: ENLE shows antinociceptive effect in dose dependent manner as compared to control (p<0.01). When compared with morphine, morphine shows significant difference in its activity (p<0.05 and p<0.01) as compared with ENLE. Effects were reduced in naloxone pre–treated rats. Conclusion: ENLE exhibited antinociceptive activity through central mechanism as compared with control. Involvement of opioidergic pathway is suggested.

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Article: Download PDF    DOI : 10.36106/ijsr  

Cite This Article:

ANTINOCICEPTIVE ACTIVITY OF ETHANOLIC NEEM (AZADIRACHTA INDICA) LEAF EXTRACT (ENLE) THROUGH OPIOID PATHWAY IN ADULT RATS, Dr. Anupam Sharma, Dr. Vipin Kumar INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-9 | Issue-2 | February-2020

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