Volume : II, Issue : IV, April - 2013

Antioxidant Activity of Thymoquinone and its Protective Effect Against Oxidative Hemolysis

Shazia Aman , Shagufta Moin

Abstract :

Reactive oxygen species (ROS) and Reactive nitrogen species (RNS) play major role in various diseases like diabetes, cancer, neurodegenerative and immunodeficiency diseases etc. Detoxification of such reactive oxygen intermediates is an essential target, yet naturally occurring antioxidants are warranted for better management of diseases. In this study, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, reducing power and Ferric Reducing Antioxidant Power assay were used for evaluating the antioxidant activity. It was also tested that whether TQ in-vitro protects red blood cells from (AAPH)induced hemolysis in diabetic and healthy subjects. It scavenges upto 78.13%. TQ demonstrated significant ferric reducing ability at very low concentrations in healthy and diabetic plasma samples. Furthermore, TQ was able to inhibit RBC hemolysis by 86.22% and 71.04% in normal and diabetic patients respectively. Our findings reveal that thymoquinone possess excellent antioxidant properties and could serve as a free radical scavenger, and this justifies its uses in alternative medicines

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Shazia Aman ,Shagufta Moin Antioxidant Activity of Thymoquinone and its Protective Effect Against Oxidative Hemolysis International Journal of Scientific Research, Vol.II, Issue.IV April 2013

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