Antioxidant and Antihyperlipidemic profile of a polyherbal formulation in patients with coronary artery disease: A Double blind placebo controlled clinical study  with an additional actives identification by LCMS

Adrija Saha; Sanchita Das; Anmol Banerjee; Bhabatosh Biswas; Santasree Mazumder

Volume : IV, Issue : I, January - 2015

Antioxidant and Antihyperlipidemic profile of a polyherbal formulation in patients with coronary artery disease: A Double blind placebo controlled clinical study with an additional actives identification by LCMS

Adrija Saha, Sanchita Das, Anmol Banerjee, Bhabatosh Biswas, Santasree Mazumder

Abstract :

Aims

The present study explores the anti-atherogenic, antioxidant property and the safety profile of the polyherbal preparation with coronary artery disease (CAD) patients of eastern India. The study will also identify the active ingredients of the herbal preparation.

Material and Patients

The study was double-blinded, randomized, placebo controlled, and was approved by the ethical committee of the R. G. Kar Medical College,

Kolkata, India. They were randomized and given either the polyherbal preparation or the identical looking placebo at a dose of 2 tablets twice

daily for a period of 3 months. Constituents of the polyherbal preparation were identified by LCMS analysis. Patients were assessed for their

routine serum parameters and oxidative stress.

Results

The chosen drug was found to elevate plasma HDL-C and Apolipoprotein A1 level, and Paraoxonase 1 activity, without altering the antioxidant status, compared to the patients treated with placebo and at the time of entry. Presence of active principles such as Coumaric acid,

catechin, caffeic acid, quercetin, n�in and ferulic acid were identified in this polyherbal preparation. The drug was safe and well tolerated among patients.

Conclusion

In view of these results as well as its non-toxicity, the polyherbal formulation appears to be a potentially safe and affordable drug for managing CAD.