Antioxidant, antiproliferative and  antimicrobial activities study of Zingiber  roseum rosc., an endangered medicinal  plant

Swarnalatha Pakalapati; Ganesh babu Devara; Anitha Mamillapalli

Volume : II, Issue : VII, July - 2013

Antioxidant, antiproliferative and antimicrobial activities study of Zingiber roseum rosc., an endangered medicinal plant

Swarnalatha Pakalapati, Ganesh Babu Devara, Anitha Mamillapalli

Abstract :

Medicinal plants are incredible; but many species are endangered due to rapid deforestation and global warming threatens. Zingiber roseum, is an endangered medicinal plant used for skin infections by the traditional healers of Eastern Ghats, India. Chloroform extract of Z. roseum rhiozome is exhibiting a proved antimicrobial activity against four different bacteria, with lowest MIC of 20 �g/ml against Staphylococcus aureus (MTCC 3160). The extract also have efficient radical scavenging activity along with reducing property by DPPH radical scavenging activity, nitric oxide scavenging activity and reducing power assay. The rhizome extract show a moderate antiproliferative activity against PC3 (Prostate cancer), SW 480 (Colon cancer), MDA MB-231 (Breast metastatic) cancer cell lines when IC 50 values compared with standards. The study concludes that the chloroform extract may be an alternative for synthetic therapeutics for treating infectious and degenerative diseases.