Volume : V, Issue : VIII, August - 2016

ANTIOXIDANTS AND ISCHEMIA MODIFIED ALBUMIN IN HYPOTHYROIDISM PATIENTS

Dr. P. T. Komala, Dr. Ursula Sampson

Abstract :

 Aim: The aim of this study was to estimate the levels of Antioxidants and Ischemia Modified Albumin in hypothyroidism patients. Reactive oxygen species (ROS) are constantly generated and eliminated in the biological system. They play an important role in normal biochemical functions and abnormal pathological functions. Ischemia Modified Albumin (IMA) is an ischemia/reperfusion injury marker which has been considered to be formed under oxidative stress conditions. Thyroid is one of the largest endocrine gland in the body. The thyroid gland, so named by Thomas Wharton in 1965. It is larger in females than in males. The structure and function of the thyroid change in different stages of the sexual cycle in females. Its function is slightly increased during pregnancy and lactation and is decreased during menopause. Materials and methods: A cross sectional study was done with 30 newly diagnosed hypothyroid patients as cases and 30 age and sex matched healthy controls. Serum levels of Antioxidants and IMA were estimated by colorimetric methods and thyroid profile was done by CLIA methodology. Results : Antioxidants and Ischemia Modified Albumin levels were found to be significantly decreased in hypothyroid patients when compared to healthy controls (p=0.00). Conclusion: We conclude that there was decrease in antioxidants and IMA levels which could be due to the consequence of ischemia which is present in hypothyroidism.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr.P.T. Komala, Dr. Ursula Sampson ANTIOXIDANTS AND ISCHEMIA MODIFIED ALBUMIN IN HYPOTHYROIDISM PATIENTS International Journal of Scientific Research,Volume : 5 | Issue : 8 |August 2016

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