Antiproliferative Activity of New Schiff Bases Derived From 3–Fluoro–5–(trifluoromethyl) benzylamine

S. Nagashree; C S. Karthik; Dr. L. Mallesha; Dr. P. Mallu; S. Bindya

Volume : III, Issue : X, October - 2014

Antiproliferative Activity of New Schiff Bases Derived From 3–Fluoro–5–(trifluoromethyl) benzylamine

S. Nagashree , C S. Karthik, Dr. L. Mallesha, Dr. P. Mallu, S. Bindya

Abstract :

A series of new 3–fluoro–5–(trifluoromethyl)benzylamine derivatives 3(a–i) were synthesized and characterized by different spectral studies. New compounds were evaluated for their antiproliferative effect using the MTT assay method against two human cancer cell lines (MCF7 and U373) and one astrocytoma ain tumor (C6 rat glioma) cell line. Among the series, compounds 3e and 3i showed good activity on all cell lines, whereas the other compounds in the series exhibited moderate activity