Volume : IV, Issue : V, May - 2015
Aryl substituted thiazolyl 4–thiazolidinopyrazoles and isoxazoles: Novel anti–microbial and anti–inflammatory agents
Iram Khan, Bhawani Singh
Abstract :
A new class of aryl substituted thiazolyl 4–thiazolidinopyrazoles and isoxazoles has been synthesized and evaluated for their anti–microbial and anti–inflammatory activities. Gram positive bacteria Bacillus cereus, and gram negative bacteria Escheria coli were used for estimation of anti–bacterial activity and Fusarium oxysporium and Aspergilus nigar fungi were used for evaluation of anti–fungal activities. In the present work, activities of synthesized compounds were evaluated by the “Disc Diffusion Method” using inhibition zone technique. The zone of inhibition was determined in comparison to the standard drugs i.e. Ciprofloxacin for bacteria and Fluconazole for fungi. The anti–inflammatory activity is expressed in percent inhibition by carrageenan induced paw oedema method using Idomethacine as standard drug. Results indicate that these compounds belong to a new class of highly potent anti–microbial and anti–inflammatory agents. Five compounds have used for the screening of anti–bacterial activity and as well as five for anti–fungal activity and three compounds evaluated as anti–inflammatory agents.
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DOI : 10.36106/ijsr
Cite This Article:
Iram Khana, Bhawani Singh Aryl substituted thiazolyl 4�thiazolidinopyrazoles and isoxazoles: Novel anti�microbial and anti�inflammatory agents International Journal of Scientific Research, Vol : 4, Issue : 5 May 2015
Number of Downloads : 624
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Iram Khana, Bhawani Singh Aryl substituted thiazolyl 4�thiazolidinopyrazoles and isoxazoles: Novel anti�microbial and anti�inflammatory agents International Journal of Scientific Research, Vol : 4, Issue : 5 May 2015
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