ASSESSMENT OF ANY DIFFERENCE IN BIOCHEMICAL PARAMETERS OF BONE MATRIX DEGRADATION AND BONE TURN OVER BETWEEN PRE, POST AND ELDERLY POST MENOPAUSAL WOMEN.

Dr. Agnihotri Bhattacharyya; Dr. Satwika Sinha

Volume : VIII, Issue : V, May - 2019

ASSESSMENT OF ANY DIFFERENCE IN BIOCHEMICAL PARAMETERS OF BONE MATRIX DEGRADATION AND BONE TURN OVER BETWEEN PRE, POST AND ELDERLY POST MENOPAUSAL WOMEN.

Dr. Agnihotri Bhattacharyya, Dr. Satwika Sinha

Abstract :

INTRODUCTION: Bone matrix component are released in the circulation throughout our life. After menopause bone resorption becomes greater than bone formation due to reduced estrogen secretion. The biochemical parameters for matrix degradation products as urinary hydroxyproline,serum calcium,enzymatic and bone turn over marker as serum alkaline phosphatase can be assessed for early diagnosis of osteoporosis. The present study was done to assess any difference in biochemical parameters of bone matrix degradation and bone turn over between pre, post and late post menopausal women. MATERIAL & METHODS: The present study has been conducted in Biochemistry Department of Calcutta National Medical College Kolkata among 80 premenopausal, 80 post menopausal and 20 elderly menopausal women attending in the thyroid OPD of the department. From the study population fasting blood and urine was collected and estimated for serum ionized calcium, serum alkaline phosphatase and urinary hydroxyproline after an informed consent with the standard laboratory procedure. RESULTS: It was found that mean Serum calcium, serum alkaline phosphatase was significantly decreased and urinary hydroxyl–proline was significantly increased in post menopausal & elderly post menopausal women than the pre–menopausal group. It was also found that UHP was positively correlated in all the groups and serum ionized calcium was correlated only in pre–menaupausal women. SUMMARY & CONCLUSION: Estimation of serum ionized calcium, alkaline phosphatase, urinary hydroxyproline can be used an easy tool for early diagnosis and early intervention in osteoposis in countries like India where estimation of bone mineral density by bone scan is costly for most of the sufferers.