ASSESSMENT OF GLUTATHIONE STATUS AND GLUTATHIONE PEROXIDASE ACTIVITY IN LUNG CANCER PATIENTS

Dr. M. Raj Kumar; Dr. A. Robert Louis; A. Lourdhu Mary

Volume : V, Issue : X, October - 2016

ASSESSMENT OF GLUTATHIONE STATUS AND GLUTATHIONE PEROXIDASE ACTIVITY IN LUNG CANCER PATIENTS

Dr. M. Raj Kumar, Dr. A. Robert Louis, A. Lourdhu Mary

Abstract :

Lung cancer is a leading cause of cancer–related mortality across the world, c� first place. It is the fifth common cancer in India. Cigarette smoke release excessive amount of free radicals such as Reactive Oxygen Species (ROS) which has the ability to induce oxidative stress and oxidative damage to the cells leading to cancer induction, a multi–step process. Oxidative stress elicited by aerobic metabolism, in human cells have developed a ubiquitous antioxidant defense system with Glutathione peroxidases (GPx), the primary cellular defense against ROS and reduced glutathione, to prevent cellular damage caused by peroxides and free radicals. Therefore the present study was focused to estimate plasma total reduced glutathione levels and glutathione peroxidase activity in lung cancer patients and controls. The study subject includes individuals newly diagnosed with lung cancer (n=50) and control (non–smokers) (n=50). Basic information such as age, sex, and smoking habit was sought using a questionnaire. The biochemical parameters were analyzed spectrophotometrically. The results of the study showed a significant reduction in the level of GSH among lung cancer patients and GPX activity was significantly increased in cases