Assessment of immuno modulatory effects of 3 PUFA in patients of predicted severe acute pancreatitis using the positive predictive value of IL6.

Prof. Shilpa A. Rao; Dr. Aditya R. Kunte

Volume : V, Issue : VI, June - 2016

Assessment of immuno modulatory effects of 3 PUFA in patients of predicted severe acute pancreatitis using the positive predictive value of IL6.

Prof. Shilpa A. Rao, Dr. Aditya R. Kunte

Abstract :

 Fish oil derived omega–3 polyunsaturated fatty acids (ω–3 PUFA) have been reported to have a beneficial effect on the immune response, hence improving outcomes in acute pancreatitis (AP). This trial was planned to assess the effect of early ω– 3 PUFA supplementation on clinical outcomes of predicted severe acute pancreatitis (PSAP) by using the positive predictive value (PPV) of IL– 6 as a marker for clinical outcomes. The PPV of IL–6 at a value of >17pg/mL was 96.5% in the control group. The number of patients who actually progressed to severe acute pancreatitis (SAP) in the ω–3 PUFA group were significantly lesser than the number predicted to progress by the cut– off value of IL–6 (p= 0.02938), thus demonstrating the effectiveness of ω–3 PUFA in improving early clinical outcomes in acute pancreatitis.