Assessment of oxidative stress status in women with Polycystic Ovary Syndrome

Dr. P.Srinivas Rao; Dr. Rakesh Sahay; Dr. D.Vijayasekhar Reddy; Dr. Deepika. M.L.N

Volume : VI, Issue : XI, November - 2017

Assessment of oxidative stress status in women with Polycystic Ovary Syndrome

Dr. P. Srinivas Rao, Dr. Rakesh Sahay, Dr. D. Vijayasekhar Reddy, Dr. Deepika. M. L. N

Abstract :

Polycystic ovary syndrome (PCOS) is a common endocrine disorders affecting 4–12% of women worldwide. It is characterized by polycystic ovaries on ultrasound scan, chronic anovulation and hyperandrogenism; allied with long term complex diseases associated with high oxidative stress. The aetio–pathophysiology of this condition is highly heterogenous involving both genes and environment.

Blood samples were collected from 400 individuals comprising 200 cases and 200 controls. Patients were selected based on Rotterdam criteria proposed by ESHRE (2003). Inter individual variation was observed among patients with respect to clinical symptoms. Forty one percent of PCOS subjects were the milder form having PCO along with oligo or anovulation and the remaining 59% were the severe form of the disease having PCO, oligo or anovulation along with clinical and/or biochemical signs of hyperandrogenism.

In order to assess the oxidative stress status in PCOS subjects the present study was carried out. The serum malondialdehyde (MDA) levels were estimated in all 400 subjects. The mean MDA levels was found to be 382.44 + 104 in patients while it was 279.97 + 94.85 in controls and differed statistically between cases and controls. Further analysis of MDA levels in milder and severe groups were 303.25 + 64.25 and 418.87 + 104.25 respectively. The mean MDA levels in milder and severe form revealed significant difference indicating higher oxidative stress in severe form of the disease compared to milder. Information on the oxidative stress status of the patient may help the clinician in the management of the condition.