Association between circulating FetuinA levels and type II Diabetes Mellitus: A systematic review and Metaanalysis of observational studies

Rekha Choudhary; Dr. P.J. Hisalkar

Volume : VI, Issue : VIII, August - 2017

Association between circulating FetuinA levels and type II Diabetes Mellitus: A systematic review and Metaanalysis of observational studies

Rekha Choudhary, Dr. P. J. Hisalkar

Abstract :

Introduction– Serum fetuin–A is a multifunctional glycoprotein which is exclusively secreted from hepatocytes in human. This study was conducted to determine the association between Fetuin–A and type 2 diabetes in different studies.

Material and Methods– literature search from different databases was done and Meta–Analysis was conducted using MOOSE guidelines. 14 full–text articles were selected among them 7 articles were used for quantitative synthesis. A total of 1011 diabetic patients were seen in the study out of 5056 participants. SPSS and Revman softwares were used for analysis.

Results– The concentration of fetuin A was found to be higher in diabetic patients. Forest plot showing combined results of seven observational studies, with three studies favouring control and four studies favours association between Fetuin–A with diabetics.

Conclusion– In conclusion, higher fetuin–A concentrations appear to be strongly associated with diabetes risk among both sexes, age (>40) years etc.