Volume : VII, Issue : II, February - 2018
ASSOCIATION OF CYTOCHROME CYP2C9 GENE POLYMORPHISM IN CARCINOMA OF OROPHARYNX AND HYPOPHARYNX
Siddararth Kumar, Sudhir Singh, Abhishek Dubey, Kirti Srivastava, Alankrita Singh, Rajeev Gupta
Abstract :
This study was carried out to investigate the association of cytochrome P450 2C9 (CYP2C9) gene polymorphism with squamous cell carcinoma (SCC) of oropharynx & hypopharynx. One hundred ten males suffering from locally advanced squamous cell carcinoma and an equal number of healthy controls were genotyped for CYP2C9*2 and CYP2C9*3, leading to poor metabolizers (PMs) by PCR–based RFLP. The frequency of genotypes of CYP2C9*2 (40%) and CYP2C9*3 (16%) were found to be significantly higher in the HNSCC controls as compared to the cases. The data suggests a significant association of the CYP2C9 polymorphism with SCC of oro & hypopharynx and underlining the importance of genotyping in determining the risk of occurrence of SCC of oropharynx & hypopharynx < clear="all" style="page–eak–before:always; mso–eak–type:section–eak" />
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DOI : 10.36106/ijsr
Cite This Article:
Siddararth Kumar, Sudhir Singh, Abhishek Dubey, Kirti Srivastava, Alankrita Singh, Rajeev Gupta, ASSOCIATION OF CYTOCHROME CYP2C9 GENE POLYMORPHISM IN CARCINOMA OF OROPHARYNX AND HYPOPHARYNX, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH :
Volume-7 | Issue-2 | February-2018
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Siddararth Kumar, Sudhir Singh, Abhishek Dubey, Kirti Srivastava, Alankrita Singh, Rajeev Gupta, ASSOCIATION OF CYTOCHROME CYP2C9 GENE POLYMORPHISM IN CARCINOMA OF OROPHARYNX AND HYPOPHARYNX, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-2 | February-2018
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