Association of Gamma Glutamyl Transferase with Metabolic Syndrome as a Diagnostic Marker

Dr. Shefali Mehta; Dr. Rajendra Triloki; Dr. Shuchi Goyal; Dr.Akhlaq Hasan

Volume : VIII, Issue : IV, April - 2019

Association of Gamma Glutamyl Transferase with Metabolic Syndrome as a Diagnostic Marker

Dr. Shefali Mehta, Dr. Rajendra Triloki, Dr. Shuchi Goyal, Dr. Akhlaq Hasan

Abstract :

Introduction: The research emphasises on the association bond of Gamma Glutamyl Transferase with Metabolic syndrome used as a marker for diagnostic. Therefore, it assists in contrast and correlates the parameters that are biochemical controls and cases. Material and Methods: The samples for the study were collected from the diagnostic centre, out–patient department and in–patient department of Medicine and Biochemistry department of RNT Medical College and M.B. Hospital, Udaipur and Central Laboratory. The observations took about a year�s time. The research was carried out on a total of 100 patients, out of which 50 cases were satisfying IDF criteria for metabolic syndrome and the remaining 50 were based on age and sex determination and controlled patients. Results: The GGT mean values, Alanine Amino Transferase (ALT), Aspartate Aminotransferase (AST) levels were statistically noted to be high in the MS group. The mean value associated with the liver enzymes in the MS group which was 51.06�6.05 for GGT, 30.87�15.85 for AST and 37.82�13.58 for ALT. The current research depicts that GGT and MS prevalence has a direct association and relation. ROC analysis states that GGT is however strongly associated with the IDF diagnostic criteria of components. Similarly, there it is seen a strong correlation amongst each of the IDF components present, except for the elevated levels of systolic blood pressure. The results show an important interdependence between GGT levels and the presence of MS. This type of result was attained after the adjustment of age, gender and based on the MS diagnosis criteria. Ultimately, the analysis based on multi–variance shows a positive correlation with the high GGT levels and CVD in contrast to low GGT found in the MS group. The analysis done was with the GGT and CVD in independent age of smoking habits. Conclusion: Increase in the number of liver enzymes, being in the normal range values, specifically considering the upper qualities, caters an important role in early diagnosis of the fats overflow to the liver details. In terms of affordability and availability with the simple tests based on routine clinical practices, specifically, the GGT have the capacity to take into account in algorithms for defined and metabolic syndrome.