IJSR - International Journal of Scientific Research

Alka Srivastava; Gaurav garg

Volume : VI, Issue : VII, July - 2017

ASSOCIATION OF SERUM COTININE LEVEL WITH CARDIOVASCULAR RISK FACTORS IN SMOKELESS TOBACCO USERS

Alka Srivastava, Gaurav Garg

Abstract :

Nicotine is a major constituent of smokeless tobacco and its addiction in smokeless form is as dangerous as smoking. As burn product of nicotine is absent but absorption from buccal mucosa leads to accumulation of metabolites which affects the cardiac parameters. To assess these effects case control study was designed. 50 ST consumers (cases) and 50 age and sex matched tobacco non users (controls) were enrolled . Anthropometry , pulse rate, bp and E.C.G .were recorded and serum cotinine level was assessed .

Strong positive relation (r>0.7) was observed between S. cotinine levels and duration of tobacco use, SBP, DBP and MAP. All correlations were significant statistically (p<0.001). Moderate positive correlation (r=0.5 to 0.7) between S. cotinine levels and pulse rate and QTc interval was observed which is significant statistically (p<0.001).