ASSOCIATION OF SERUM LEPTIN LEVELS WITH METABOLIC SYNDROME (MetS) AND ITS COMPONENTS IN ADULT POPULATION OF SAURASHTRA, GUJARAT

Chaitanya G. Chinawale; Milav H. Bhavsar; Hardik N. Javia; Nishant R. Bhimani; Dipak V. Parmar

Volume : VI, Issue : IV, April - 2017

ASSOCIATION OF SERUM LEPTIN LEVELS WITH METABOLIC SYNDROME (MetS) AND ITS COMPONENTS IN ADULT POPULATION OF SAURASHTRA, GUJARAT

Chaitanya G. Chinawale, Milav H. Bhavsar, Hardik N. Javia, Nishant R. Bhimani, Dipak V. Parmar

Abstract :

Background: Metabolic syndrome (MetS) is a common metabolic disorder resulting from the increasing prevalence of obesity; hyperleptinemia/leptin resistance is thought to be a cause of obesity. The present study is aimed to assess the association of serum leptin levels with MetS in the population of Saurashtra region, Gujarat.

Methods: In this cross–sectional observational study, 297 individuals aged between 20 to 80 years were included. The details of demographics, personal and family history of diseases, addiction/s etc. were collected from each participant. Blood samples were analyzed for lipid profile, fasting blood sugar and serum leptin levels.

Results: Serum leptin levels were found significantly high in the individuals with MetS and leptin level were positively correlated with BMI, WC, FBS, SBP and DBP. The ability of serum leptin levels to predict MetS was assessed by ROC curve; AUC were 0.737 and 0.769 in males and females respectively. Binary logistic regression analysis suggested the relative risk of developing MetS, independent of age, BMI and tobacco usage as OR 1.20 and 1.10 in males and females respectively.

Conclusion: Leptin level increases with increase in components of MetS and is found to be associated with MetS. Independent of age, BMI and tobacco usage, leptin levels are associated with abdominal obesity, high BP and high FBS which are known risk factors for cardiovascular diseases. Hence, leptin can be used as a biomarker for MetS and cardiovascular risk.