ASSOCIATION OF VITAMIN D DEFICIENCY AND OXIDATIVE STRESS STATUS IN RELATION TO GLYCEMIC INDEX FLUCTUATIONS IN T2DM PATIENTS.

Dr. Madhumita Chatterjee; Faruque Ahmed

Volume : VIII, Issue : II, February - 2019

ASSOCIATION OF VITAMIN D DEFICIENCY AND OXIDATIVE STRESS STATUS IN RELATION TO GLYCEMIC INDEX FLUCTUATIONS IN T2DM PATIENTS.

Dr. Madhumita Chatterjee, Faruque Ahmed

Abstract :

Background: VitaminD has been associated with extra–skeletal pathologies through mechanisms involving inflammatory and oxidative stress processes deficiency of Vitamin D has been associated with increase result of developing Type 2 diabetes mellitus (DM) and cardiovascular diseases.

Material and Methods: A total of 276 subjects both males and females, age between 35–65 years were enrolled for this study in which 140 were type 2 diabetic and 136 were without diabetes. Fasting blood sugar (FBS) was measured by glucose oxidase and peroxidase method. Serum MDA was measured by thiobarbituric acid reactive substances method. GlycatedHemoglobin (HbA1c) was measured by ion–exchange resin method. Serum 25(OH)D measurement were performed using a chemiluminescaceimmunoassay analyzer.

Result : The MDA and fasting blood glucose levels were increase in diabetes and were statistically significant. Vitamin D levels were significantly low in patients of type 2 diabetics where compared to controls (p<0.000)

Conclusions and Clinical Significance:From this investigation it is reasoned thatlower levels of vitamin D is associated with increased oxidative stress .Therapeutic intervention to increase the vitamin D levels and reduce the oxidative stress should be incorporated as a part of treatment in type 2 diabetics.