Bacterial and fungal profile of corneal ulcers of patients attending Integral Institute of Medical Sciences & Research(IIMS&R) Lucknow

Manzoor Ahmed Thokar; Talib Ansari; Rubie Malhotra

Volume : IX, Issue : I, January - 2020

Bacterial and fungal profile of corneal ulcers of patients attending Integral Institute of Medical Sciences & Research(IIMS&R) Lucknow

Manzoor Ahmed Thokar, Talib Ansari, Rubie Malhotra

Abstract :

total of fifty corneal ulcer samples were collected & processed for bacterial & fungal study. The study showed that 80% (40 out of 50) samples were positive for growth of either fungus or bacteria, there was no growth seen in 10 samples (healthy individuals). Among 40 positive samples, 13 (32.5%) samples showed positive bacterial isolates whereas 27 (67.5%) samples were positive for fungal keratitis. Corneal ulceration was encountered in all age groups in this study with preponderance among 30–70 years of age group, The prevalence was higher in males than females attributing to 60% of total samples. Male preponderance in bacterial keratitis was 53.8% whereas in fungal keratitis came out to be 62.9% respectively. Among bacterial isolates, gram positive bacteria were more predominant than gram negative bacteria & showing incidence of 83.6% and 23.07% respectively. The commonest bacterial isolates were Staphylococcus aureus (53.8%) and Pseudomonas aeruginosa (23.07%). Vancomycin, teicoplanin and linezolid showed 100% sensitivity for gram positive bacterial isolates followed by gentamycin (71%) & P. aeruginosa isolates showed 100% sensitivity with ceftazidime/clavulanic acid, cefepime, polymixin B and colistin sulphate whereas 66.66% sensitivity was found in gentamycin and tazobactam, aztreonam, meropenem and & low sensitivity of 33.33% was seen with piperacillin. All strains of P.aeruginosa were found resistant to levofloxacin and ciprofloxacin. Fungal isolates of Fusarium spp. 33.33% , Aspergillus flavus 14.81% and Aspergillus niger 14.81% were grown in our study. Organic matter was found to be most common predisposing factor in microbial keratitis & unilateral eye was mostly affected in our study.