Bauhinia forficata and glucocorticoidinduced insulin resistance

Beatriz Bertolaccini Mart�nez; Ana Carolina Couto Pereira; J�lio Henrique Muzetti; Fernando de Paiva Telles; Fiorita Gonz�les Lopes Mundim; Manoel Ara�jo Teixeira

Volume : VI, Issue : X, October - 2017

Bauhinia forficata and glucocorticoidinduced insulin resistance

Beatriz Bertolaccini Mart Nez, Ana Carolina Couto Pereira, J Lio Henrique Muzetti, Fernando De Paiva Telles, Fiorita Gonz Les Lopes Mundim, Manoel Ara Jo Teixeira

Abstract :

PURPOSE: To evaluate the effects of Bauhinia forficata in model of glucocorticoid–induced insulin resistance.

MATERIAL AND METHODS: Wistar rats were divided into groups according to the treatment they received, for ten consecutive days, dexamethasone (D), n=10; dexamethasone–Bauhinia (DB), n=15; dexamethasone–Metformin (DM), n=15; and dexamethasone–Bauhinia–Metformin (DBM), n=11. Blood samples for laboratory analysis were obtained and liver fragments were taken for analyzing glycogen and fatty. This study has been approved by Universidade Vale do Sapuca� Ethics Committee on Animal Usage.

RESULTS: Insulinemia (mU/l): D=0.2�0.1 vs DB=1.19�0.6 p=0,01; and DM=1.32�0.6; p=0.01); Homeostasis Model Assessment (HOMA)–b: D=0.2�0.1 vs DB=2.52�0.9 p=0,04; and DM=2.51�1.5; p=0.001); HOMA–IR: D=0.2�0.1 vs DB=1.12�0.5 p=0,001and DM=1.11�0.5 p=0,001. Histological examination of the liver showed that 100% of group D and 66% of group DB had moderate fatty (p=0.02).

CONCLUSION: Animals with glucocorticoid–induced insulin resistance and treated with Bauhinia forficata decoction did not present decreased insulinemia and increased peripherical sensitivity to insulin action.