Volume : IV, Issue : VII, July - 2015

BENIGN MIMICKERS OF GALL BLADDER CARCINOMA IN CHOLECYSTECTOMY SPECIMENS: HISTOPATHOLOGICAL STUDY

Taha M M. Hassan, Anil Mohan Rao. S

Abstract :

<p><p> Carcinoma of the gallbladder (GBC) clinically mimics many benign gallbladder diseases and often escapes detection until advanced stage. Despite the frequency of cholecystectomies, diagnosis of GBC remains problematic in many situations. The aim of this study is to analyze many pathological mimickers of GBC, which may be associated with overdiagnosis and underdiagnosis of this malignancy, as well as to show the prevalence of GBC in a local region of KSA. This analytical retrospective study was performed on 1500 cholecystectomy specimens which were collected through 4 years from 7 governmental Hospitals located in one region in KSA. the surgical materials were received in the central Histopathology laboratory situated in Arar city. Majority of surgical cholecystectomy specimens were done for cholelithiasis. Rokitansky–Aschoff sinuses (RAS) are one of the most important benign mimickers of GBC, they are found in 7.1% of the studied specimens, and adenomyomatosis is another mimicker which was seen in 2%,of gall bladder specimens, whereas GBC diagnosed in 0.8% of cholecystectomy specimens. This study concluded that accurate pathological evaluation of gall bladder disease through patient‘s history in conjunction with clinical high index of suspicion are prerequisites to detect GBC. Detection of GBC at an early stage is difficult because the symptoms mimic benign gallbladder diseases. Misinterpretation of subtle microscopic abnormalities contributes diagnostic failures in early cases of GBC. Careful attention to any evidence of mural thickening, thorough sampling, particularly in older patients, and close examination of any deeply situated glandular structures are critical.</p></p>

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Taha M M. Hassan, Anil Mahon Rao. S Benign Mimickers of Gall Bladder Carcinoma in Cholecystectomy Specimens: Histopathological Study International Journal of Scientific Research, Vol : 4, Issue : 7 July 2015


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