Biochemical risk factors for cardiovascular nephropathy in nephrotic syndrome: relationship with oxidative stress, total antioxidant capacity and minerals during remission.

Dr. Jyoti Dwivedi; Dr. P. D. Sarkar

Volume : VIII, Issue : IV, April - 2019

Biochemical risk factors for cardiovascular nephropathy in nephrotic syndrome: relationship with oxidative stress, total antioxidant capacity and minerals during remission.

Dr. Jyoti Dwivedi, Dr. P. D. Sarkar

Abstract :

Nephrotic syndrome (NS) associated with cardiovascular complications and it is life–threatening complication. Nephrotic syndrome is often manifesting in progression of cardiovascular nephropathy. Therefore, this study was carried out to investigate oxidant and antioxidant status in nephrotic syndrome and cardiovascular nephropathy patients. The blood samples were analyzed for quantitation of malondialdehyde as index of lipid peroxide, vitamin C, total antioxidant capacity, homocysteine, lipoprotein (a) and lipid profile, total protein and albumin with copper and zinc. Significantly increased levels of serum total cholesterol, triglycerides, low density lipoprotein, malondialdehyde as index of lipid peroxide, lipoprotein (a), homocysteine (p<0.001) and decreased levels of serum total antioxidant capacity, total protein, albumin, high density lipoprotein & plasma vitamin C (p<0.001), copper and zinc were noticed in the patients with nephrotic syndrome and cardiovascular nephropathy as compared to control and remission subjects