Volume : VI, Issue : IV, April - 2017
Biochemical risk factors for diabetic nephropathy in nephrotic syndrome: relationship with oxidative stress, total antioxidant capacity and minerals during remission.
Dr. Jyoti Dwivedi, Dr. P. D. Sarkar
Abstract :
Diabetic nephropathy is the single most common disorder leading to renal diseases. Reactive oxygen species (ROS) play a major role in the development of diabetic nephropathy. Nephrotic syndrome is often manifesting in progression of diabetic nephropathy. Therefore, this study was carried out to investigate oxidant and antioxidant status in nephrotic syndrome and diabetic nephropathy patients. The blood samples were analyzed for quantitation of malondialdehyde as index of lipid peroxide, vitamin C, total antioxidant capacity, homocysteine, lipoprotein (a) and lipid profile, total pprotein and albumin with copper and zinc. Significantly increased levels of serum total cholesterol, triglycerides, low density lipoprotein, malondialdehyde as index of lipid peroxide, lipoprotein (a), homocysteine (p<0.001) and decreased levels of serum total antioxidant capacity, total protein, albumin, high density lipoprotein & plasma vitamin C (p<0.001), copper and zinc were noticed in the patients with nephrotic syndrome and diabetic nephropathy as compared to control and remission subjects.
Keywords :
Malondialdehyde (MDA) Total antioxidant capacity (TAC) vitamin C (vit C) Diabetic nephropathy (DN) Lipoprotein (a) Homocysteine (HCY) Reactive oxygen species.
Article:
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DOI : 10.36106/ijsr
Cite This Article:
Dr. Jyoti Dwivedi, Dr. P. D. Sarkar, Biochemical risk factors for diabetic nephropathy in nephrotic syndrome: relationship with oxidative stress, total antioxidant capacity and minerals during remission., INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : VOLUME-6 | ISSUE-4 | APRIL‾2017
Number of Downloads : 334
References :
Dr. Jyoti Dwivedi, Dr. P. D. Sarkar, Biochemical risk factors for diabetic nephropathy in nephrotic syndrome: relationship with oxidative stress, total antioxidant capacity and minerals during remission., INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : VOLUME-6 | ISSUE-4 | APRIL‾2017
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