Volume : IV, Issue : IX, September - 2015

Bisphenol A: Cause of male infertility

Dr. Seema Srivastava, Ms. Priya Gupta

Abstract :

<p><p>The aim of this study was to evaluate the effect of bisphenol A (BPA), a contaminant of resin–based dental composites and sealants, on the fertility of male adult wistar albino rats. Adult male albino rats of strain weighing approx.150–200gm. were divided into four groups of 10 each. BPA (5, 50 and 100 µg /100gm/bw) was administered orally daily to the rats in the test groups and olive oil to the control group for 90 days. Male fertility was assessed periodically by mating each rat with two untreated females. There were significant reductions in the absolute weights of the testes and disrupted spermatogenesis was observed at 50 and 100µg dose level of BPA whereas at 5 µg dose level did not show any such significant effect. Epididymal epithelium degeneration was observed at 5, 50 and100µg dose level. Cauda sperms were found to be reduced in the 100µg dose treated animals. Reduction in the serum testosterone was also observed in treated animals. Study concludes that bpa affects reproduction with impaired fertility in male rats.</p></p>

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Seema Srivastava Bisphenol A: Cause of Male Infertility International Journal of Scientific Research, Vol : 4, Issue : 9 September 2015

Number of Downloads : 1148

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