Volume : II, Issue : V, May - 2013

BISPHENOL–A COMMONLY ADDED RESIN IN PLASTIC GOODS AS PRECIPITATING FACTOR FOR HORMONAL DISRUPTIONS AND INSULIN RESISTANCE SYNDROME IN AFFECTED FEMALES

Dr Seema Mishra

Abstract :

 The chemical added in plastics, specially recycled plastic has Bisphenol–A, some previous India based studies showed that Bisphenol addition is many times more than the global level, [ more than 77.36 ppb], It‘s used in the production of various types of food and drink containers, compact discs, electronics and automobile parts, Some polycarbonate containers — especially water bottles having Bisphenol should marked with the code number 7 on the bottom, but this is not followed in India in common practice. This pollutant precipitates significantly low levels of progesterone, extremely high levels of testosterone, hence Polycystic ovary syndrome..[PCOS] .

But the most disastrous effect is Bisphenol stimulates excessive production of Insulin, finally Insulin Resistance Diabetes [ Type –II Diabetes ] is developed. As this potent toxic chemical is added unlimited in cold beverages , produced by multi–national companies, so in present study we take female subjects working in plastic industries, adolescent girls, who are drinking four to six bottles of one specific soft drink , their hormonal profile of Estrogen, Progesterone, Cortisol and C– peptide were estimated. : Seventy women (12–35 years of age ) with PCOS based on clinical suspicions were compared with 10 normal women.

Mean body mass index (BMI) was 21.6 kg/m2 in normal women, 27.44 kg/m2 in overweight subjects(n=44) and 31.86 kg/m2 in obese subjects (n=21). Mean waist: hip ratio (WHR) was 0.82 in normal women and 0.83 in subjects. Seventy percent subjects were overweight, among whom 46.93% had high LH: FSH ratio, 59.18% had hyper androgenism and 44.2% been hirsute, having significantly high BMI and total testosterone (TT). Sixty percent subjects were hyper androgenic with high basal insulin BI in 35.7%. 62.8% fulfilled sonographic criteria for diagnosing PCOS – 70.45% of them bilateral, 22.72% only left–sided and 6.81% only right sided. 59.3% were hirsute and 38.6% hyper insulinemic (BMI and TT were significantly high). Positive predictive value for TT was 64.44% and for LH: FSH 55.55%.

As High TT level is the single most diagnostic criterion. Hyper insulinemia is related to hyper androgenism. Body weight was related to ovarian stroma and hirsutism. The study showed that Bisphenol A poisonings has significantly adverse effect on hormonal profile of the subjects and this condition is strongly co–related with occurrence of PCOs and Diabetes in females.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr Seema Mishra, BISPHENOL-A COMMONLY ADDED RESIN IN PLASTIC GOODS AS PRECIPITATING FACTOR FOR HORMONAL DISRUPTIONS AND INSULIN RESISTANCE SYNDROME IN AFFECTED FEMALES, International Journal of Scientific Research, Vol.II, Issue.V May 2013

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