BISPHENOL–A EXPOSURE IMPRINTS EXPRESSION OF GENES (HOXA–10 & HOXA–11), BCL–2 PROTEIN AND INCEDENCE OF RESORPTION IN EARLY GESTATION ALBINO RAT

T.GEETHARATHAN; P. JOSTHNA

Volume : V, Issue : IV, April - 2016

BISPHENOL–A EXPOSURE IMPRINTS EXPRESSION OF GENES (HOXA–10 & HOXA–11), BCL–2 PROTEIN AND INCEDENCE OF RESORPTION IN EARLY GESTATION ALBINO RAT

T. Geetharathan, P. Josthna

Abstract :

The widespread use of Bisphenol–A (BPA) in polycarbonate plastics has raised concerns regarding potential estrogenic effects on normal development and adult function of the reproductive system in humans and animals. The BPA is the most estrogenitically active molecule present in plastics. Human infants may also be exposed to environmental estrogens. Bottle fed infants are most likely exposed to BPA. This study tested the hypothesis that maternal BPA exposure cause female reproductive tract defects. Pregnant rats were orally treated from gestational day 8th to 15th with a dose of BPA (50 mg/kg & 500 mg/kg ) that resulted in resorptions, changes the expression levels of anti apoptotic protein Bcl–2 in placenta, uterus and alter the gene expression levels (HOXA–10 & HOXA–11 genes) in uterus. The results of the current study indicate that environmental estrogens, such as the BPA at physiological concentrations, cause adverse affects on the developing and adult female reproductive system.