Blepharospasm: a rare adverse effect caused by long-term administration of olanzapine

Dr.Anil Kumar Khatik; Dr.Pooja Dixit; Dr.Sushil Kherada; Dr Suresh Gocher; Dr.Dheeraj Goya

Volume : VIII, Issue : XI, November - 2019

Blepharospasm: a rare adverse effect caused by long-term administration of olanzapine

Dr. Anil Kumar Khatik, Dr. Pooja Dixit, Dr. Sushil Kherada, Dr Suresh Gocher, Dr. Dheeraj Goya

Abstract :

Olanzapine is an atypical (second generation) antipsychotic primarily used for schizophrenia and bipolar disorder . Its common side effects are weight gain, metabolic disturbances including high cholesterol and diabetes mellitus . Blepharospasm is an abnormal involuntary blinking or contraction of muscles of eyelids (orbicularis oculi, proceres and corrugated superciliaris). Blepharospasm is an uncommon adverse effect of Olanzapine and is thought to occur due to blockage of D2 dopamine receptor in the basal ganglia . We are reporting a case of 48 year old female , a known case of chronic schizophrenia since 12 years , who developed blepharospasm while taking olanzapine 20mg.