Volume : VIII, Issue : XI, November - 2019

C-peptide and cardiovascular diseases

Deepika Loona, Sukhraj Kaur, Pashaura Singh Sandhu

Abstract :

Introduction: Cardiovascular diseases (CVD) are a major cause of death and disability throughout the world. This group of disorders is preceded by atherosclerosis which is usually the underlying pathology and develops many years earlier to the time the symptoms occur. Although many molecules have been considered, C–peptide has been shown to play a major role in atherogenesis. Aim: The present study was thus planned to study the role of C–peptide in various cardiac disorders. Material and Methods: The study comprised of 100 patients of various cardiac disorders and 100 apparently healthy normal individuals served as controls. All the subjects were investigated for baseline parameters i.e. Fasting plasma glucose, Glycated hemoglobin, Lipid profile and C–peptide. Body Mass Index was also calculated. Results: Body Mass Index increased significantly in male patients as compared to controls (p<0.05). Both Fasting plasma glucose and Glycated hemoglobin along with Total cholesterol, Triglycerides, Low Density Lipoprotein–Cholesterol, Very Low Density Lipoprotein–Cholesterol increased significantly (p<0.05) in both male and female patients as compared to controls whereas High Density Lipoprotein–Cholesterol decreased highly significantly (p<0.001) in female patients as compared to controls whereas change in male patients was significant (p<0.05). The HDL–C: LDL–C ratio was atherogenic in these individuals. Levels of C–peptide also increased significantly (p<0.001) in patients with cardiac disorders as compared to normal individuals. Conclusion: C–peptide once deposited in the sub endothelial space may promote inflammation and lower High Density Lipoprotein–Cholesterol levels, thus it can be postulated that increased levels of C–peptide are associated with cardiac disorders.

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Article: Download PDF    DOI : 10.36106/ijsr  

Cite This Article:

C-PEPTIDE AND CARDIOVASCULAR DISEASES, Deepika Loona, Sukhraj Kaur, Pashaura Singh Sandhu INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-11 | November-2019

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