Carbapenemase Producing Bacteria in clinical Isolates from Tertiary Care University Hospital in Bangladesh

Anwarul Haque; Qumrul Huda; Amirul Islam; Tomoko Ehara; Takashi Okanda; Kiyofumi Ohkusu; Ruhul Amin Miah; Tetsuya Matsumoto

Volume : VIII, Issue : III, March - 2019

Carbapenemase Producing Bacteria in clinical Isolates from Tertiary Care University Hospital in Bangladesh

Anwarul Haque, Qumrul Huda, Amirul Islam, Tomoko Ehara, Takashi Okanda, Kiyofumi Ohkusu, Ruhul Amin Miah, Tetsuya Matsumoto

Abstract :

Carbapenem–resistant bacteria are concerned for increased outeaks of resistant infections and mortality rates across the world. Carbapenemase–producers are particularly important because of location of their enzyme–coding gene in mobile genetic elements, facilitating dissemination of resistance in different bacteria. We studied 1212 bacterial isolates in clinical samples in Bangladesh, where 600 were multi–drug resistant (MDR) and 114 (114/600,19%) were resistant to carbapenem. Forty–eight isolates (48/600,42.1%) were producing blaNDM, blaVIM and blaOXA –type carbapenemase. Many of them were also co–harboring extended spectrum b–lactemase (ESBL)–producing genes. This study introduced several novel bacteria carrying resistant genes and variants of NDM and OXA–type in Bangladesh. Evident burden and distribution of MDR bacteria in Bangladesh indicates that the developing regions in Asia are potential resource for surveillance of unrecognized threat to global health and thus this region should be thoroughly monitored to prevent spreading of antibiotic resistant infections across the globe.