Volume : IV, Issue : XII, December - 2015

CELL TOXICITY AND CYTOCHROME P450 METABOLISM OF SOME QUINAZOLINE–4–ONES

Ben Farrar, Jasim Al Ndash Rawi, Michelle Gibson

Abstract :

A selection of novel quinazoline compounds were investigated in this study for their cell toxicity and cytochrome P450 metabolism effects. All of the compounds have a morpholino substitution on position 2, a carbonyl substitution on position 4 and various substitutions on positions 7 and 8 which may be benzylamine groups or pyridine–methyl groups. None of the compounds were cytotoxic to HeLa cells with no significant cell death (P>0.05). The functional groups on position 7 were structurally closely related but had some significantly different cytochrome P450 metabolism profiles for CYP2C19, CYP2D6, CYP2E1 and CYP3A4. These cytochromes were chosen because they are responsible for some 79% of all xenobiotic metabolism in the liver. Compounds closely related to these have shown anti–microbial, DNA–PK inhibition and potassium channel effects.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Ben Farrar, Jasim Al–Rawi, Michelle Gibson Cell Toxicity and Cytochrome P450 Metabolism of Some Quinazoline-4-Ones International Journal of Scientific Research, Vol : 4, Issue : 12 December 2015

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