CHANGES IN QTC INTERVAL WITH ONDANSETRON VS PALONOSETRON IN PROPHYLAXIS OF POSTOPERATIVE NAUSEA AND VOMITING IN SUBJECTS UNDERGOING GENERAL ANAESTHESIAA RANDOMIZED CONTROLLED TRIAL

DR. SAMPA DUTTA GUPTA; DR. SAIKAT BHATTACHARYA; DR. TANUSHREE MONDAL; COL. (DR) A.K. SINGH; DR. SAUMYA BISWAS; DR. HARIPADA DAS

Volume : V, Issue : V, May - 2016

CHANGES IN QTC INTERVAL WITH ONDANSETRON VS PALONOSETRON IN PROPHYLAXIS OF POSTOPERATIVE NAUSEA AND VOMITING IN SUBJECTS UNDERGOING GENERAL ANAESTHESIAA RANDOMIZED CONTROLLED TRIAL

Dr. Sampa Dutta Gupta, Dr. Saikat Bhattacharya, Dr. Tanushree Mondal, Col. Dr A. K. Singh, Dr. Saumya Biswas, Dr. Haripada Das

Abstract :

Aim: To evaluate two different doses of intravenous ondansetron and palonosetron in causing changes in QTc and also their effectiveness in preventing postoperative nausea and vomiting in patients undergoing general anaesthesia. Patients & Methods: This prospective, randomized, double blind, placebo control study was done on a total 150 patients undergoing general anaesthesia. Patients were randomized to receive any one of the two doses of intravenous palonosetron (0.025mg, 0.075mg) [Grp.P0.025 & Grp.P0.075] or ondansetron (4mg, 8mg) [Grp. O4 & Grp.O8] or placebo immediately before induction. The primary end–point was to find the changes in QTc values from pre–injection to 5 minutes after injection of study drugs. Time needed for first rescue antiemetic medication was the secondary end point. Results: Post–injection QTc values in all groups receiving ondansetron and palanosetron were found significantly higher than the placebo group. Grp. O8 recorded maximum QTc prolongation. Between 60 to 120 minutes of injection of study drugs, 93.33% of Group O4 and 23.33% of Group O8 patients required rescue antiemetic. Whereas first rescue antiemetic was not required in any patient of the palonosetron groups before 120mins and none of the patients of the Group P0.075 required any antiemetic before 240 mins. Conclusion: The efficacy of intravenous palonosetron in controlling postoperative nausea vomiting and its safety profile in respect to QTc prolongation in patients under general anaesthesia is superior to that of intravenous ondansetron.