Changes in serum alkaline and acid  phosphatase levels in relation to ageing and onset of  osteoporosis among South Indian rural women

R.Bharathi

Volume : IV, Issue : VII, July - 2015

Changes in serum alkaline and acid phosphatase levels in relation to ageing and onset of osteoporosis among South Indian rural women

R. Bharathi

Abstract :

Bone modeling is an ongoing skeletal metabolic process involving a continuous formation as well as resorption of bone in human life cycle. Gradually as the child grows the osteoblastic activity increases and with the advancing age, the osteoclast activity predominates and leads to imbalance in bone turnover process. This increases porosity in bones and is the primary cause of osteoporosis in ageing population. The existing literature well defines serum alkaline phosphatase as bone formation marker and serum acid phosphatase as resortion marker.The present study aimed at studying the changes in these two enzymes with the advancing age and the onset of osteoporosis. The study is carried out in 260 South Indian rural women between 35 to 74 years of age. The results well demonstrated the elevation these two bone turnover markers with the progressive age and also as the bone density regressed from normal to osteopenia and to osteoporosis.