Characteristics of Healthcare Associated Bloodstream Infections in Neonates Operated and Managed in a Tertiary care Paediatric Surgical Neonatal Intensive Care Unit

Suchitra Mishra; V.S Randhawa; Suraiya K. Ansari; Chadha R

Volume : V, Issue : VI, June - 2016

Characteristics of Healthcare Associated Bloodstream Infections in Neonates Operated and Managed in a Tertiary care Paediatric Surgical Neonatal Intensive Care Unit

Suchitra Mishra, V. S Randhawa, Suraiya K. Ansari, Chadha R

Abstract :

 Context: Healthcare associated primary bloodstream infections in operated neonates. Aims: To characterise the primary healthcare associated bloodstream infections (HCABSIs) in neonates operated and managed in a neonatal intensive care unit of northern India, a critical aspect inadequately addressed till now Settings and Design: Prospective, observational study Methods and Material: Neonates were assessed and those with foci of infection prior to/ at admission were excluded. Statistical analysis used: Statistical testing was conducted with the statistical package for the social science system version SPSS 17.0 Results: The infection rate was found to be 16.84 episodes per hundred admissions. The infection density was found to be 16.67 episodes per thousand patient days. Majority of the infections set within the first seven days of life. The maximum numbers of eleven HCABSIs were reported in operated cases of tracheoesophageal fistula, in which Acintobacter spp was the predominant pathogen. Klebsiella pneumoniae was the predominant pathogen in operated cases of intestinal obstruction and omphalocele. Eighteen percent of K.pneumoniae isolates and thirty seven percent of Acinetobacter spp were resistant to imipenem. Birth weight, duration of stay and positive C–reactive protein (CRP) were significant risk factors associated with primary HCABSIs (p<0.05), however according to multivariate analysis, duration of stay was found to be the only statistically significant factor (p=0.005, OR–1.169, 95% CI: 1.047–1.304). Conclusions: Primary HCABSI infection rate was 16.84 episodes per hundred admissions and birth weight, duration of stay and positive CRP were significant risk factors.