Clinical and microbiological profile of blood culture positive Salmonella sp in Delhi: A Hospital based study.

Dr Shiv Sekhar Chatterjee; Dr Shilpee Kumar; Dr Sushil Kumar Chumber; Dr Uma Khanduri

Volume : VII, Issue : VI, June - 2018

Clinical and microbiological profile of blood culture positive Salmonella sp in Delhi: A Hospital based study.

Dr Shiv Sekhar Chatterjee, Dr Shilpee Kumar, Dr Sushil Kumar Chumber, Dr Uma Khanduri

Abstract :

To improve the selection of an appropriate antimicrobial agent and to understand the clinical and microbiological characteristics of bacteremic Salmonella sp, a laboratory–based surveillance of blood culture positive Salmonella sp was conducted during two year period in a tertiary care hospital. The clinical profile and antibiotic usage were obtained from Hospital Information system and medical record department. 16649 patient�s blood samples received for blood culture and sensitivity test. Of these 501 (3.01%) patients� blood yielded Salmonella sp (S.Typhi 385; S.ParatyphiA 116, a ratio of 3.32). It was isolated throughout the year but peaked in April–May. Paediatric age group constitutes quarter of the burden of enteric fever. All patients presented with fever (100%), followed by pain abdomen (33%), vomiting (27%), diarrhoea (18%), constipation (4%), splenomegaly (30%) and hepatomegaly (20%). Complications were seen in 5% cases. No mortality was observed. The antimicrobial sensitivity of Ampicillin was 92%, Ceftriaxone 94%, Ciprofloxacin 39%, Levofloxacin 33%, Cotrimoxazole 88.2%, Chloramphenicol 87% and MDR observed in 4%. The most commonly used antibiotics were 3rd generation Cephalosporin. Enteric fever is a significant public health problem in Delhi. It is important to be aware of local antibiotic sensitivity pattern as limited options are available to commence the treatment empirically.