Clinical and Radiological features of Central Giant Cell Granuloma of jaws  A systematic review and meta analysis.

Dr. Mubeen Khan; Dr. Kondajji Ramchandra Vijayalakshmi; Dr. Taranpreet Kaur

Volume : VI, Issue : II, February - 2017

Clinical and Radiological features of Central Giant Cell Granuloma of jaws A systematic review and meta analysis.

Dr. Mubeen Khan, Dr. Kondajji Ramchandra Vijayalakshmi, Dr. Taranpreet Kaur

Abstract :

Background: The central giant cell granuloma (CGCG) of the jaws is a relatively uncommon pathologic lesion, accounting for less than 7% of all benign jaw lesions.

Objectives: This systematic review and meta – analysis is intended to assess the clinical and radiological features of CGCG of jaws, based on data provided in the literature.

Methods:

Data sources: The databases searched for the systematic review include PUBMED, MEDLINE, COCHRANE LIBRARY and LILACS.

Study eligibility criteria: Original research articles in which clinical and radiological features of CGCG of jaws have been assessed are included in the systematic review.

Results: In the pooled proportions of population with CGCG of jaws, displacement of adjacent structures occurred in 37%, well – defined borders in 60%, expansion in 65%, multilocular lesions in 45%, pain in 12%, perforation of tissues in 38%, root resorption in 17% and the lesions recurred in 20%.

Limitations: Selection of only observational studies and published articles might have led to selection and publication bias respectively in the study.

Conclusion: CGCG of jaws present with diverse clinical and radiographic features. A number of original research studies based on standardized protocols and with a significant population are required for improvement in diagnosis and management of this lesion.

Implication of key findings: Based on the present data, it implies that knowledge about varied clinical and radiographic features of CGCG is extremely important to arrive at an accurate diagnosis. However, differentiation between aggressive and non– aggressive CGCGs should be considered to improve treatment planning and prognosis.