Clinical effects of levamisole and antioxidants and their effects on serum immunoglobulins IgG, IgA and IgM: A comparative clinical study in management of OSMF.

Dr Akshay Sharma; Dr Sonam Tyagi; Dr Saddam

Volume : IX, Issue : I, January - 2020

Clinical effects of levamisole and antioxidants and their effects on serum immunoglobulins IgG, IgA and IgM: A comparative clinical study in management of OSMF.

Dr Akshay Sharma, Dr Sonam Tyagi, Dr Saddam

Abstract :

Background and Objectives: Oral submucous fiosis (OSMF) is considered as an oral precancerous condition that shows characteristic inflammation and progressive fiosis of the submucosal tissues that leads to marked rigidity as well astrismus. OSMF till date remains a dilemma to the oral pathologists due to its ambiguous pathogenesis and overlapping classification systems.OSMF is linked with alterations in serum immunoglobulins levels. Aim:This study was conducted to evaluate the clinical effects of levamisole and antioxidants and their effects on serum immunoglobulins IgG, IgA and IgM levels. Materials and Methods:45 study participants were enrolled for the study. Subjects were assigned randomly into 3 sub–groups. There were 15 patients per group; group I comprised of patients who received levamisole, 50 mg thrice daily for three alternate weeks, group II comprised of patients who received 2 capsules of antoxid daily for six weeks, group III comprised of patients who received levamisole and antioxidant both. Results:Paired�t� test and unpaired�t� test were used to assess the study results. The results were clearly indicative of the advantage oftaking levamisole, antoxid and the combination of levamisole and antoxid in improving mouth opening and reducing burning sensation of mouth significantly. Significant decrease in serum IgG, IgA and IgM was observed in group I and combination group III whereas in the group II significant reduction was only seen in serum IgA and IgM levels. Conclusion: Levamisole alone has a higher advantage in clinical management of OSMF when compared to that of antioxidant therapy alone or in combination. Antioxidants proved to have no added benefit in aiding to the reduction in burning sensation or in opening of restricted oral cavity.