CLINICAL PROFILE OF ACUTE FEBRILE ILLNESS WITH THROMBOCYTOPENIA IN TERTIARY CARE CENTRE OF ROHILKHAND REGION, UTTAR PRADESH

Volume : VII, Issue : VI, June - 2018

Rawal M P, Kalia Shivam, Grover Ankit, Mehrotra M K, Johri Sharat

INTRODUCTION– Fever is defined as an elevation of the body temperature above the normal circadian rhythm as a result of the change in the

thermoregulatory centre located in the anterior hypothalamus. An AM Temperature of > 98.9 F or a PM temperature of >99.9 f would define fever.

The objective of this study was to describe clinic–laboratory profile and outcome of acute feile illness with thrombocytopenia in a tertiary care

centre located in Rohilkhand region of Uttar Pradesh.

MATERIALS AND METHODS– This was an observational prospective study carried out in a tertiary care centre located in Rohilkhand region In

Uttar Pradesh Between 1st june 2017 to 31st September 2017. 100 Patients were Included in the study who presented with Fever of Less than a

week�s duration with thrombocytopenia and were subjected to Investigation and specific treatment.

RESULTS– Total number of patients taken into study were 100 who presented with Fever <1 week and thrombocytopenia , Platelet count <1.5

Lakh who were admitted in Medicine Department at Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh.

Out of 100 Patients, 52% patients were diagnosed as cases of Dengue, 40% patients of Malaria, 4% patients of leptospirosis and 4% patients of

Hepatitis. Most common symptom reported by the patients was fever in patients of Dengue (50.7%), Malaria (55%) and Leptospira (75%), and

Headache for patients of Hepatitis. 17.3 % of patients suffering from Dengue reported with a Purpuric rash whereas 22.5% of patients suffering

from malaria reported headache.

As far as thrombocytopenia was concerned, 30.7% patients of Dengue had Platelet count in the range of 20001–40000, 26.9 % in the range of

40001–60000, 21.1% in the range of 1–20000, 11.5% in the range of 60001–80000 and 9.8% in the range of 80001–100000.

In Patients of Malaria, 35% of the cases had platelet count in the range of 20001–40000, 25% patients in the range of 60001–80000, 17.5% each in

the range of 40001–60000 and 80001–100000, whereas only 5% patients had platelet count between 1–20000.

No death was reported and all patients responded to conservative management.

CONCLUSION– This study will be helpful for the development of rational guidelines for the control of infectious diseases and specific treatment

to prevent complications, morbidity and mortality. Dengue fever and Malaria remain the common causes of Acute Feile Illness with

Thrombocytopenia and may become a major mortality Disease with poor outcome