Volume : V, Issue : VIII, August - 2016
Clinical study of efficacy and toxicity profile of Antiretroviral Treatment regimens in resource restricted settings. –Original Article
Dr. Umesh Bhoi, Dr. Shekhar N Pradhan, Dr Sudarshan Gaurkar, Dr. Amruta Kamble
Abstract :
Background: When AIDS was first recognized in 1981, patients with the disease were unlikely to live longer than a year or two. Since the development of an effective arsenal of drugs that can help many people infected with HIV live longer and healthier lives. Aims: The present study was conducted to compare efficacy of different antiretroviral regimens in form of immunological and virological success and drug toxicity of anti retroviral treatment. Materials and Methods: Study was conducted in resource restricted setting on 230 HIV positive patients who are on antiretroviral treatment to compare efficacy and toxicity. Assessment was done with clinical, virological and immumnological criteria at baseline, 3 months interval and at 48 weeks. Results: All of the five regimens studied had increased CD4 count at the 48 weeks of antiretroviral therapy. Success rate is higher in double PI regimen (86.7%) while lowest in 2NRTI regimen (56.6%). The Efavirenz, Nevirapine, single PI based regimen had almost same (>80%) success rate. Failure rate was highest in 2NRTI regimen (44.7%) while lowest in double PI regimen (13.3%) Most of the adverse effects are associated with Stavudine i.e. peripheral neuritis and lipoatropy. Serious adverse effects were seen with Nevirapine.
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DOI : 10.36106/ijsr
Cite This Article:
Dr. Umesh Bhoi, Dr. Shekhar N Pradhan, Dr Sudarshan Gaurkar, Dr. Amruta Kamble Clinical study of efficacy and toxicity profile of Antiretroviral Treatment regimens in resource restricted settings. –Original Article International Journal of Scientific Research,Volume : 5 | Issue : 8 |August 2016
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Dr. Umesh Bhoi, Dr. Shekhar N Pradhan, Dr Sudarshan Gaurkar, Dr. Amruta Kamble Clinical study of efficacy and toxicity profile of Antiretroviral Treatment regimens in resource restricted settings. –Original Article International Journal of Scientific Research,Volume : 5 | Issue : 8 |August 2016
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