Clinical Utility of Glutathione–S–Transferase, Alkaline Phosphatase and Lactate Dehydrogenase activity in Stomach Cancer Patients before and after chemotherapy for diagnosis and prognosis

Ranjit.S.Ambad; Dr. Suryakant Nagtilak; Dr. M. R. Jape

Volume : V, Issue : I, January - 2016

Clinical Utility of Glutathione–S–Transferase, Alkaline Phosphatase and Lactate Dehydrogenase activity in Stomach Cancer Patients before and after chemotherapy for diagnosis and prognosis

Ranjit. S. Ambad, Dr. Suryakant Nagtilak, Dr. M. R. Jape

Abstract :

Purpose: – To analyze the level of serum glutathione–s–transferase (GSTs), Alkaline Phosphatase (ALP) and Lactate Dehydrogenase (LDH) activity in patients of stomach cancer before and after chemotherapy. Methods: – For the study total 42 cases of carcinoma of stomach of stage II and stage III (after and before chemotherapy) were selected. All patients were clinically and histological diagnosed. 40 age and sex matched healthy normal subjects selected as control. GSTs, ALP, and LDH activity was measured in the serum of control group (n=40) and in patients with stomach cancer (n=50). Results: –Mean GSTs, ALP, and LDH activity in serum was significantly higher in patients with stomach cancer as compared to control group (p<0.001). The patients of stomach cancer after chemotherapy had significantly elevated activity of serum GSTs, ALP, and LDH than before chemotherapy. Conclusion: – In this study, we concluded that Serum GSTs measurement in plasma maybe useful tumor marker in stomach cancer and serum GSTs activity might be helpful to predict the response of chemotherapy in advance stages of cancer. Increased level of LDH and ALP can be use as a prognostic factor and serum LHD and ALP good indicator of stages and bulk of tumor, LDH is also a good prognostic factor in advanced GIT cancer treated with chemotherapy, ALP level greater than 500U/L over a period of 6 month may be indicative of advanced disease progression, which wants a more aggressive treatment. These findings of serum enzyme prompt us to adjust treatment strategies ahead of time, considering for diagnosis and prognosis in both the stages.