CLINICO – HISTOPATHOLOGICAL CORRELATION IN LEPROSY: A TERTIARY CARE HOSPITAL BASED STUDY AT UDAIPUR.

Dr. Richa Parakh; Dr. Vishal Mulchandani; Dr. Kriti Kothari Parakh

Volume : IV, Issue : X, October - 2015

CLINICO – HISTOPATHOLOGICAL CORRELATION IN LEPROSY: A TERTIARY CARE HOSPITAL BASED STUDY AT UDAIPUR.

Dr. Richa Parakh, Dr. Vishal Mulchandani, Dr. Kriti Kothari Parakh

Abstract :

Background and Objectives: Leprosy is a chronic, infectious disease caused by Mycobacterium leprae, affecting mainly cutaneous and peripheral nervous system. Histopathology is an important tool to diagnose leprosy in situations where it mimics other clinical conditions. This study was conducted to know the correlation between clinical and histopathological diagnosis of leprosy. Methods: Sixty cases were included over a period of 18 months, in whom leprosy was clinically diagnosed or suspected and biopsies were sent for histopathological confirmation. Histopathological findings are graded according to Ridley and Jopling scale. Clinicopathologic correlation was done along with Fite–Faraco stain. Results: 41(68.3%) were males and 19(31.60%) were females. Most common clinical feature was loss of sensation. Most common histological type was Borderline Tuberculoid seen in 22(36.66%) cases followed by Borderline Lepromatous 18(30%) cases, Tuberculoid 10(16.66%), Lepromatous Leprosy 4(6.66%), Histoid 2(3.33%) and Borderline Borderline 1(1.66%). Majority (58.3%) of cases were paucibacillary type and rests (41.6%) were of multibacillary type. Fite–Faraco staining was positive in 25(41.66%) cases. Clinico–histopathological correlation was observed in 41(68.3%) cases. Conclusions: This study emphasis on correlation of clinical and histopathological features along with bacterial index to be more useful than considering any of the single parameters alone for accurate diagnosis of leprosy