Volume : VII, Issue : XII, December - 2018

CLINICO-IMMUNOLOGICAL PROFILE OF PATIENTS WITH MULTIPLE MYELOMA AND CORRELATION WITH RESPONSE TO FIRST LINE THERAPY AT A TERTIARY CARE CENTRE IN INDIA

Dr K Satyanand, Dr Sanjeevan Sharma, Dr Gaurav Mahajan, Dr Ajay Kumar

Abstract :

 

Multiple myeloma (MM) is a clonal plasma cell neoplasm characterized by end organ damage in the form of renal impairment, lytic bony lesions, hypercalcemia and anemia. Management of MM has improved substantially over the past two decades. This study was undertaken to delineate the clinico–immunological profile of MM patients treated at our hospital and to assess their response to first line chemotherapy.

Materials and Methods

In this study, we retrospectively analyzed the medical records of all multiple myeloma patients who were managed at this 1000–bedded tertiary care center from early 2006 to Sep 2018. Myeloma was diagnosed using standard criteria. The conventional chemotherapy used at our center is three drug combination chemotherapy and response assessment was done at 4–6 months of induction therapy.

Results

Out of a total of 82 patients of MM, 62 were males and 20 were females. The median age was 63 years. The most prominent clinical symptom was bone pain. Six patients had plasmacytoma. 27 patients had anaemia (Hb<8 gm%) while 20 had serum creatinine ≥2 mg/dl. The monoclonal serum paraprotein in majority of patients (62 out of 82) was IgG. The overall objective response rate (complete response [CR] + very good partial response [VGPR] + partial response [PR]) was 78.05% with ≥VGPR in 85.94% of them.

Conclusion

Multiple myeloma is a disease with a variable clinical presentation involving multiple organ systems. The clinico–immunological profile of our study is comparable to the published data both Indian as well as globally.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

CLINICO-IMMUNOLOGICAL PROFILE OF PATIENTS WITH MULTIPLE MYELOMA AND CORRELATION WITH RESPONSE TO FIRST LINE THERAPY AT A TERTIARY CARE CENTRE IN INDIA , Dr K Satyanand, Dr Sanjeevan Sharma, Dr Gaurav Mahajan, Dr Ajay Kumar , INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7|Issue-12| December-2018


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