CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF GASTROINTESTINAL STROMAL TUMORS

Dr. Dhanashri D. Khonde; Dr. Sadhana H. Khaparde; Dr. Sanjay D. Deshmukh; Dr. Baba B. Shinde

Volume : IX, Issue : I, January - 2020

CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF GASTROINTESTINAL STROMAL TUMORS

Dr. Dhanashri D. Khonde, Dr. Sadhana H. Khaparde, Dr. Sanjay D. Deshmukh, Dr. Baba B. Shinde

Abstract :

(A) Objectives: The prognosis of Gastrointestinal stromal tumors (GIST) largely depend upon the histopathological characteristics and immunohistochemistry marker studies. This study is undertaken to study clinicopathological and immunohistochemical features of these tumors. (B) Materials and Methods: A 6 years retrospective study (2014–2019) was conducted at a tertiary care hospital. It included all the 15 cases of GIST diagnosed in that period. Histopathology slides and clinical records of all the cases were reviewed. Appropriate blocks were selected and sent for immunohistochemistry marker study which included: DOG–1, CD117, S–100, desmin, smooth muscle actin (SMA), CD34 and vimentin. (C) Results: Out of 15 cases of GIST, all presented as abdominal masses commonly located in small intestine of adult men with mean age being 56 years. All the GISTs showed positivity for CD117 and vimentin. Immunoreactivity for DOG–1 clone 1.1 was observed in 14 cases and DOG–1 clone k9 was positive in 2 out of 15 cases studied. (D) Conclusion: This study validates the importance of CD117 in diagnosis of GIST. Out of two clones of DOG–1, clone 1.1 was observed to be more sensitive marker