Clinicopathological Features of Triple Positive (luminal B her-2 positive) Breast Cancer: A retrospective Analysis

Volume : VII, Issue : V, May - 2018

Dr. Sumita A Jain, Dr. Anil Kumar Khyalia

Aim

•The aim is to study various clinicopathological features of TPBC in Northern part of INDIA.

Background:

• Molecular classification of east cancer is based on gene expressing profile.

• The subgroup [luminal A, luminal B, HER2, and basal like] have distinct gene expression pattern andphenotypical characteristics.

• TPBC shares phenotypical features with HER–2 +VE east cancer,

• The luminal B/HER2+ve patients had a lower risk of mortality than the luminal B/HER2–ve for all stages of disease.

• TPBC have younger age of presentation and younger patients have more aggressive presentation, which is associated with worseprognoses.

• the pathological complete response (pCR) rate was consistently lower when compared with HER2+ve and basal–like subtypes

Material And Method:

• Study Design: Hospital based retrospective, descriptive type of observational study.

• Study place: Dept. of general surgery SMS hospital Jaipur.

• Study population: 402 cases of diagnosed east cancer.

• Statistical Analysis: Descriptive statistics.

Result:

• Total east cancer patients studied = 402

• 38 patients [9.5%] were found to have TPBC

• Most [73.7 %]28 were before the age of 45 years.

• More common in pre menopausalwomen[76.3 %]29

• Most of TPBC [97.3 %] had histological features of IDC

Conclusions:

TPBC represents around 10 % of east cancer.

TPBC is commonly associated with premenopausal status.

TPBC is commonly occurs in UOQ and infiltrative duct carcinoma(IDC) is the most common .