Volume : VII, Issue : V, May - 2018

CLINICOPATHOLOGICAL STUDY OF LICHEN AMYLOIDOSIS

Dr. R. Rajesh, Dr. M. Prabakaran

Abstract :

Background: Lichen amyloidosis is a type of primary localized cutaneous amyloidosis where there is deposition of amorphous amyloid substance in the dermis without the involvement of internal organs. It is not an uncommon disorder but there are only limited studies from south India. Aim: To study the clinical features, demographic patterns and associations of lichen amyloidosis along with correlation of clinical and histopathological findings.Methods:In this study,30 patients with clinical diagnosis of lichen amyloidosisattending Dermatology clinic of a tertiary care hospital in South India were evaluated clinically and skin biopsy is taken for histopathological examination after an informed consent.Results: A total of 30 patients were included in the study. Of the 30 cases, there were 19 males and 11 females. Majority of patients were in the age group of 31 – 50 years. Itching is the most commonpresenting complaint. Most of the patients (76.67%) had history of chronic friction and in few (10%) there was a positive family history. Pretibial region (96.67%) is the commonest site involved followed by forearm (26.63%) and arm (16.67%) in this study.  Histopathologicalyhyperkeratosis and acanthosis were seen in all the cases, eosinophilic amyloid mass was seen in papillary dermis along with lymphohisticytic infiltrate in most of the cases. Conclusion: Lichen amyloidosis is common in middle age with a slight male preponderance. Pretibial region is the commonest site of involvement and chronic friction has a major role in its development. Histopathology is helpful in confirming the diagnosis and usage of Congo red stain is more sensitive in detecting amyloid deposits.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr.R.Rajesh, Dr.M.Prabakaran, CLINICOPATHOLOGICAL STUDY OF LICHEN AMYLOIDOSIS, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-5 | May-2018

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