Volume : IX, Issue : V, May - 2020

CO-RELATION OF VITAMIN D LEVELS WITH LEFT VENTRICULAR EJECTION FRACTION IN PATIENTS WITH DILATED CARDIOMYOPATHY.

Tiwari Avanish, Mehrotra M. K, Seth Saksham

Abstract :

Dilated Cardiomyopathy is an important cause of sudden cardiac death (SCD) and heart failure (HF),is the leading indication for cardiac transplantation in children and adults worldwide. It is characterized by ventricular chamber enlargement and systolic dysfunction and normal left ventricular wall thickness. Different etiologies can lead to DCMP, such as inherited, infectious and inflammatory diseases. The majority of cases remain unexplained after a thorough review for secondary cause. Vitamin D plays a vital role in maintaining serum calcium and phosphate levels for bone mineralization and optimal skeletal health. Recent literature has indicated a much oader role of Vitamin D than simply the regulation of calcium metabolism as Vitamin D receptors (VDRs) are found in a variety of cells and tissues. These include normal cells of the immune system, kidney, heart, and vasculature and malignant east, colon, and prostate cells. The heart is particularly noteworthy in that plasma 25–hydroxyvitamin D3 [25(OH) D3] levels have been shown to correlate inversely with the incidence of a variety of cardiac disorders including ischemic heart disease and heart failure. Role of Vitamin D in myocardial contractility was demonstrated in a community study of 870 elderly patients without heart disease during which higher circulating Vitamin D levels were found to correlate with better left ventricular (LV) systolic function and smaller LV end–systolic diameter (LVESD).In this study 51 patients were included and vitamin D assay was done by using VIDAS technique and hence divided into Sufficient, Deficient and Insufficient levels. Left Ventricular Ejection Fraction was measured with M–Mode 2D–echo. The normal LVEF was taken as 50 – 70%, Mild dysfunction – 40–49%, Moderate dysfunction – 30–39% and Severe dysfunction as LVEF < 30%.Severeity of ejection fraction was co–related with the levels of Vitamin D. This showed a significant co–relation between them with P–value of 0.0023.Hence we concluded with our study that the more severe the vitamin D levels the more severe was ejection fraction in patients with DCMP.

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Article: Download PDF    DOI : 10.36106/ijsr  

Cite This Article:

CO-RELATION OF VITAMIN D LEVELS WITH LEFT VENTRICULAR EJECTION FRACTION IN PATIENTS WITH DILATED CARDIOMYOPATHY., Tiwari Avanish, Mehrotra M.K, Seth Saksham INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-9 | Issue-5 | May-2020

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