Co–relation of Serum Ferritin, Iron, TIBC levels with Morphological Grading of Bone Marrow Iron Stores in Bone Marrow Aspiration Studies

Lt Col Ankur Ahuja; Lt Col GPS Gahlot; Gp Capt Renu Madan; Lt Col Sunita; Brig Kavita Sahai; Dr Chetan Agarwal; Dr Beenu Singh

Volume : VII, Issue : IX, September - 2018

Co–relation of Serum Ferritin, Iron, TIBC levels with Morphological Grading of Bone Marrow Iron Stores in Bone Marrow Aspiration Studies

Lt Col Ankur Ahuja, Lt Col Gps Gahlot, Gp Capt Renu Madan, Lt Col Sunita, Brig Kavita Sahai, Dr Chetan Agarwal, Dr Beenu Singh

Abstract :

Background: Measurement of bone marrow iron (hemosiderin) by histochemical Prussian blue/Perl�s staining is taken as gold standard to diagnoseiron status/iron overload and to differentiate morphologically similar anemia due to chronic disorder versus nutritional causes.

Aims: To evaluate dynamics of iron metabolism in various conditions.

Study design: This prospective study was performed in cases who have undergone bone marrow aspiration to access the bone marrow iron stores

Subjects & methods: To correlate serum levels of ferritin, iron, total iron binding capacity with morphological bone marrow aspiration iron Gale�s grading in 100 consecutivecases.

Statistical Analysis Used: Chi–square and Spearman correlation tests were done using SPSS 18.0 software (IBM Inc).

Results: Statistical data proved that P value of BM iron grading is < 0.001 with both serum ferritin and TIBC, however overall correlating best with serum ferritin (Spearman correlation 0.865) as compared to TIBC and serum iron.