Comparative effects of Clozapine and Quetiapine on metabolic profile, serum Prolactin and QTc interval in Treatment-Resistant Schizophrenia

Dr.Mitesh Kumar; Dr.B.S.Chavan; Dr.Ajeet Sidana; Dr.Subhash Das

Volume : VII, Issue : V, May - 2018

Comparative effects of Clozapine and Quetiapine on metabolic profile, serum Prolactin and QTc interval in Treatment-Resistant Schizophrenia

Dr. Mitesh Kumar, Dr. B. S. Chavan, Dr. Ajeet Sidana, Dr. Subhash Das

Abstract :

Objective: To compare the effect of clozapine and quetiapine on metabolic parameters, serum Prolactin and QTc in patients with treatment–resistant schizophrenia (TRS).

Method: In this prospective, randomized, open label study, 40 patients (20 each in two groups) with schizophrenia (ICD 10) and fulfilling modified version of Conley and Kelly�s criteria of TRS received either clozapine or quetiapine in therapeutic dose for 14 weeks after a 7–day washout period. The final mean (SD) doses were 322.1(52.50) mg/day for clozapine group and 790(30.78) mg/day for quetiapine group. Patient�s weight, Body mass index (BMI), fasting blood glucose (FBS), cholesterol, triglyceride, HDL, LDL, VLDL, serum Prolactin and QTc interval on ECG were measured using standard protocol at baseline, 6 weeks, 10 weeks and 14 weeks. Two groups were compared for change in levels from baseline of various variables at 6, 10 and 14 weeks.

Results: Clozapine group had significantly greater (<0.05) rise in weight, BMI, cholesterol, triglyceride, VLDL at 6, 10 and 14 weeks and in LDL at 10 and 14 weeks than quetiapine group. Quetiapine led to significantly higher increase in QTc interval on ECG at 10 and 14 weeks than clozapine. However, no significant difference was present between two groups on change in levels of FBS, HDL and serum Prolactin.

Conclusions: Clozapine was found to be associated with higher metabolic side–effects than quetiapine. However, quetiapine was associated with greater QTc elevation than quetiapine. Both the drugs were similar with respect to change in serum Prolactin level.