Comparative evaluation of Antinociceptive effects of Ramipril, Telmisartan, Diclofenac and Tramadol in Wistar Rats.

Dr Upender Kumar; Dr Amandeep Singh; Dr M. A. Beg; Dr Shalu Bawa; Dr SB Dutta; Dr Mohd. Anjoom; Dr Hitender Kumar

Volume : VII, Issue : V, May - 2018

Comparative evaluation of Antinociceptive effects of Ramipril, Telmisartan, Diclofenac and Tramadol in Wistar Rats.

Dr Upender Kumar, Dr Amandeep Singh, Dr M. A. Beg, Dr Shalu Bawa, Dr Sb Dutta, Dr Mohd. Anjoom, Dr Hitender Kumar

Abstract :

Background:NSAIDs and Opioidsare most widely used analgesics but prolonged use causes serious adverse reactions.Studieshave shown Renin angiotensin system plays a role in modulatingpain.

Aim:Antinociceptive effects of Ramipril and Telmisartan werecomparedwith Diclofenac and Tramadol using tail flick method.

Material and Methods:Study was conducted in Pharmacology department,SGRRIM&HSfor 6months.30Wistar ratswere divided in fivegroups(n=6):Group1(Diclofenac10mg/kg)Group2(Tramadol10mg/kg)Group3(Ramipril1mg/kg)Group4(Telmisartan10mg/kg)andGroup5(Control;Normalsaline0.2ml).Tail flick response was noted at 0,30,60,90,120 and180minutes afteroral administration of drugs. pvalue<0.05 wassignificant.

Results:Intragroup comparison showed significant results in Groups 1 to 4 during study period(p<0.05).On intergroup comparison at 90 minutes,Groups1 to4 showed significant difference when compared with group 5(p< 0.001).No significant difference was seen between Diclofenac vsTramadol group(p>0.05).Significant difference(p<0.001)was seen when Diclofenac and Tramadol were compared with Ramipril and Telmisartan.

Conclusion:Antinociceptive effects were seen with Ramipril and Telmisartan but showed weaker analgesic effects when compared with diclofenac and tramadol.