COMPARATIVE EVALUATION OF EFFECT OF LOSARTAN AND AMLODIPINE AS MONOTHERAPY ON SERUM URIC ACID LEVELS IN PATIENTS OF HYPERTENSION WITH HYPERURICAEMIA

Dr.Nidhi Sharma; Dr.Gurpreet Kaur Randhawa; Dr.Rajiv Sharma

Volume : VII, Issue : III, March - 2018

COMPARATIVE EVALUATION OF EFFECT OF LOSARTAN AND AMLODIPINE AS MONOTHERAPY ON SERUM URIC ACID LEVELS IN PATIENTS OF HYPERTENSION WITH HYPERURICAEMIA

Dr. Nidhi Sharma, Dr. Gurpreet Kaur Randhawa, Dr. Rajiv Sharma

Abstract :

Randomised, prospective, comparative study was conducted in Government Medical College, Amritsar. 60 patients of hypertension with hyperuricaemia were assigned into two groups of 30 patients each. Group A was treated with Losartan 50mg and group B received Amlodipine 5mg, once daily orally. BP was recorded every 2 weeks for 12 weeks and serum uric acid was monitored every 4 weeks for 12 weeks. Systolic /diastolic blood pressure decreased by14.80/10.13 mm Hg respectively in group A and by 14.20/11.53 mm Hg respectively in group B which was highly significant (p < 0.001). Intergroup difference was non–significant. SUA reduction with losartan (22.69%) was more as compared to amlodipine (4.45%) and difference was statistically significant (p<0.05). Both the drugs were well tolerated in both the groups. Losartan was more efficacious in hypertensive patients with concomitant hyperuricaemia than amlodipine.